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GERD is the chronic version of this problem, and untreated GERD can lead to Barretts esophagus and, rarely, esophageal cancer

In urinary and male reproductive tract infections caused by uropathogenic Escherichia coli (UPEC), UPEC suppresses the host cell AKT signaling pathway via its virulence factor -hemolysin, resulting in a marked reduction in histone H4 acetylation levels (ChIP-qPCR shows P 60% to ~20%thereby inhibiting ASC-mediated assembly and activation of the NLRP3 inflammasome [282]

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Selective coactivation of 7- and 42-nicotinic acetylcholine receptors reverses beta-amyloidinduced synaptic dysfunction